This is one way how Devolution occurs
Cytosine Methylation Affects the Mutability of Neighboring Nucleotides in Germline and Soma
Excerpt from abstract: "Methylated cytosines deaminate at higher rates than unmethylated cytosines, and the lesions they produce are repaired less efficiently. As a result, methylated cytosines are mutational hotspots. Here, combining rare polymorphism and base-resolution methylation data in humans, Arabidopsis thaliana, and rice (Oryza sativa), we present evidence that methylation state affects mutation dynamics not only at the focal cytosine but also at neighboring nucleotides. In humans, contrary to prior suggestions, we find that nucleotides in the close vicinity (±3 bp) of methylated cytosines mutate less frequently. Reduced mutability around methylated CpGs is also observed in cancer genomes, considering single nucleotide variants alongside tissue-of-origin-matched methylation data. In contrast, methylation is associated with increased neighborhood mutation risk in A. thaliana and rice. The difference in neighborhood mutation risk is less pronounced further away from the focal CpG and modulated by regional GC content. Our results are consistent with a model where altered risk at neighboring bases is linked to lesion formation at the focal CpG and subsequent long-patch repair. Our findings indicate that cytosine methylation has a broader mutational footprint than is commonly assumed."
My comment: Ecological adaptation to diet types, climate, stressors, toxicants, sensory stimuli, pheromones etc. is controlled by epigenetic mechanisms and factors. Changing methylation patterns result in genetic errors mostly due to tendency of methylated cytosines turning to thymines in deamination. Not all errors are repaired and many of them end up into germline. This is called mutational load. Every time human DNA is passed from one generation to the next it accumulates 100–200 new mutations. There are 1,134,942 disease-related genetic errors in human genome worldwide. About half of human pathogenic SNPs (Single Nucleotide Polymorphism) are GC>AT point mutations and they are strongly linked to epigenetic modifications.
In organisms in nature, genetic errors lead often to speciation. The more adaptation and variation resulting in epigenetic modifications, the more genetic errors. This is easily observed as loss of chromosomes within diploid organisms.
Within humans, there is no speciation happening. We are experiencing rapid genetic degradation but there will not be human sub-species. Isn't it interesting that the Bible tells us the truth about this biological fact? Evolution never happened.
Gen. 1: 21 "And God created great whales, and every living creature that moveth, which the waters brought forth abundantly, after their kind, and every winged fowl after his kind: and God saw that it was good."Human (no variation):
Gen. 1:27 "So God created man in his own image, in the image of God created he him; male and female created he them."
