About 20,000 new disease-causing genetic mutations in 2017 in the human DNA at population level - Today the total number is 214,158
https://www.ncbi.nlm.nih.gov/pubmed/28349240?dopt=AbstractMy comment: Modern scientists are not aware of random beneficial mutations in the human DNA. Even the famous lactose tolerance is not based on genetic mutations, but on different methylation levels of the MCM6 regulatory gene.
http://sciencerefutesevolution.blogspot.fi/2017/02/lactase-persistence-genotype-data-is.html
Rapid genetic degradation is a scientific fact all over nature. It can be observed as gene loss, decreasing number of chromosomes, increasing amounts of heterochromatin in genomes, shortening life spans, susceptibility to diseases, bacteria turning to parasitic or pathogenic bacteria etc. You can easily find information about the Madeira Mouse who lost over half of its chromosomes just in 500 years or the Red Fox who has 1,500 protein-coding genes fewer than its ancestors. Or the Red Muntjac who has only 3 pairs of chromosomes left. There are no mechanisms resulting in evolution due to rapid genetic degradation. Changes we can observe in organisms are due to epigenetic control of gene expression OR loss of genetic information. Don't be deceived.