There are 3 billion base pairs in the human genome, and a mistake or mutation in just one single letter can have a significant impact on a person's health
https://www.latimes.com/science/sciencenow/la-sci-sn-dna-gene-editing-20171025-story.html
Excerpt: "In the new study, published Wednesday in the journal Nature, the authors present a second base editor that can convert the base adenine (A) into the base inosine (I), which acts like guanine (G).
The new work is significant because it will allow scientists to use base editing to address many more single-letter mutations than was previously possible, said Krishanu Saha, a biomedical engineer at the University of Wisconsin Madison who was not involved with the research.
"This is another nice example of using protein engineering to diversify the types of edits that the CRISPR system can accomplish," he said.
There are 3 billion base pairs in the human genome, and a mistake or mutation in just one single letter can have a significant impact on a person's health.
Of more than 50,000 genetic changes currently known to be associated with disease in humans, 32,000 of those are caused by the simple swap of one base pair for another, Liu said.
The group's first base editing tool, which had the effect of converting a C to a T, has the potential to correct 14% of human diseases associated with a single-letter mutation. The new tool will allow researchers to address an additional 48% of these types of diseases.
The type of mistake that can be targeted by the new base editor is "by far, the most common kind" in people "and probably all living systems," Liu said."
The new work is significant because it will allow scientists to use base editing to address many more single-letter mutations than was previously possible, said Krishanu Saha, a biomedical engineer at the University of Wisconsin Madison who was not involved with the research.
"This is another nice example of using protein engineering to diversify the types of edits that the CRISPR system can accomplish," he said.
Of more than 50,000 genetic changes currently known to be associated with disease in humans, 32,000 of those are caused by the simple swap of one base pair for another, Liu said.
The group's first base editing tool, which had the effect of converting a C to a T, has the potential to correct 14% of human diseases associated with a single-letter mutation. The new tool will allow researchers to address an additional 48% of these types of diseases.
The type of mistake that can be targeted by the new base editor is "by far, the most common kind" in people "and probably all living systems," Liu said."
My comment: Here's a brief summary of facts regarding genetic entropy:
- There are 628,685 gene-disease associations in human genome worldwide (DisGeNet, Jan 2019)
- There are 628,685 gene-disease associations in human genome worldwide (DisGeNet, Jan 2019)
- Every time human DNA is passed from one generation to the next it accumulates 100–200 new mutations, according to a DNA-sequencing analysis of the Y chromosome.
- Exome Aggregation Consortium (ExAC) released a report after analyzing the genome of over 60,000 individuals. 1,2 billion genes were analyzed and not a single beneficial mutation was found.
- The list of human genetic diseases is very long.
- Modern science is not aware of random, fully beneficial DNA mutations.
- Honest scientists realize that human genetic degradation is an inevitable phenomenon
- Rapid genetic degradation is occurring everywhere in the wild.
