2023/04/15

Genetic entropy is a biological fact

Genetic entropy is a biological fact


Genetic entropy means that information content in the genome is inevitably corrupting or declining. Time is an enemy for information. This is due to mutations, random errors, that accumulate in cells of all kind of organisms. Genetic entropy is an observed phenomenon. There is a lot of scientific evidence supporting this:

  1. Human mutation rate

    https://www.nature.com/articles/news.2009.864

    "Every time human DNA is passed from one generation to the next it accumulates 100–200 new mutations, according to a DNA-sequencing analysis of the Y chromosome."

  2. A total absence of random, fully beneficial DNA mutations in human genome. Instead, there are 1,134,942 harmful genetic errors in human genome worldwide. That number comes from DisGeNet database and it's outdated. The true number should be more than 2 million. A huge number of genetic errors in human genome can be observed as high prevalence of rare genetic disorders. One in five 'healthy' adults may carry disease-related genetic mutations.

  3. A huge number of LoF-variants in human genome:

    https://pure.mpg.de/rest/items/item_2327171_2/component/file_2327170/content

    "Genome-sequencing studies indicate that all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome. Here we apply stringent filters to 2951 putative LoF variants obtained from 185 human genomes to determine their true prevalence and properties...However, recent studies examining the complete genomes of apparently healthy subjects have suggested that such individuals carry at least 200  and perhaps as many as 800 predicted LoF variants."

    There are only <20,000 protein coding genes in human genome, which means 200-800 LoF variants is a significant proportion of erroneous DNA in the whole genome.

  4. There's a deletional bias shaping bacterial genomes. Lenski's Long Term Experiment clearly proves that evolution has not taken place after more than 80,000 generations of bacteria. The famous citrate utilization was due to rearrangement of DNA. No new information.

  5. The more adaptation or selective breeding, the more genetic errors. This can easily be observed in the wild and in cattle or dog breeding

    Evolution believers claim there is no such thing as Genetic Entropy. They claim that diseases caused by genetic errors belong to evolution. This is a weak argument, because there are several clever DNA repair mechanisms in the cell. However, DNA repair mechanisms don't work with 100% efficiency and that's why gene pools are rapidly deteriorating. 

    A few years ago we were taught that so called non coding DNA, that was believed to be junk-DNA, could serve as a buffer against harmful mutations. Today, there is no junk-DNA but Genetic Entropy remains. Evolution never happened.

    Synonyms for Genetic Entropy: Genetic load, mutational load, genetic degradation, genetic decay.