Researchers obtained fruit fly lines having the same DNA sequence but different eye colors
https://phys.org/news/2017-04-mechanism-epigenetic-inheritance.htmlSame DNA, different color. Researchers have obtained drosophila epilines—that is, genetically identical lineages with distinct epigenetic characteristics—with white, yellow, and red eyes respectively. They achieved this by transiently disturbing interactions between target genes and PcG proteins, which are complexes involved in the repression of several genes governing development. Cavalli and his team at the Institute of Human Genetics (University of Montpellier / CNRS) are the first to show that regulation of gene position can lead to transgenerational inheritance.
DNA is not the only medium for communicating information necessary for cell function. Cell processes are also determined by the chemical labeling (or marks) and specific spatial organization of our genomes, which are epigenetic characteristics—that is, nongenetic but nonetheless inheritable traits. Epigenetic marks include modifications of histones, the proteins around which DNA is wound. PcG proteins, on the other hand, play a regulatory role by affecting 3-D chromosomal configuration, which establishes certain interactions between genes in the cell nucleus. The position of a gene at any given moment determines whether it is active or repressed.
Through temporary disruption of these interactions, the scientists were able to produce Drosophila epilines characterized by different levels of PcG-dependent gene repression or activation. They verified that these epilines were indeed isogenic, or genetically identical, by sequencing the genome of each. Despite their identical DNA, the integrity of epilines—and the unique phenotypic characteristics they program—can be maintained across generations. But this phenomenon is reversible. Crosses between drosophilas with over- or underexpressed genes and others having no such modifications to gene activity "reset" eye color without altering the DNA sequence, thus demonstrating the epigenetic nature of this inheritance.
The researchers then showed that new environmental conditions, such as a different ambient temperature, can affect the expression of epigenetic information over several generations, but they do not erase this information. Such transient effects of environmental factors to which earlier generations were exposed on the expression of characteristics in their progeny illustrate the unique, pliable nature of this epigenetic mechanism. By conducting "microcosm" experiments that recreated natural environmental conditions, the researchers—working with INRA—confirmed that epigenetic inheritance in Drosophila can be maintained in the wild.
Giacomo Cavalli's crew has therefore proven the existence of Polycomb-mediated stable transgenerational epigenetic inheritance dependent on 3-D chromosomal structure. Their findings offer new horizons for biomedical science. They suggest that epigenetics could partly solve the mystery of "missing heritability"—that is, the absence of any apparent link between genetic makeup and certain normal hereditary traits and diseases."
My comment: Human eye color is also regarded as polygenic trait which means there's no one certain gene in response of determining eye color. Pigment production and regulation is instead controlled by epigenetic factors and mechanisms.This means that also skin color and hair color variation are regulated by epigenetic factors. Modern science has revealed that human characteristics are not determined by DNA sequences. This is why the theory of evolution is the most serious heresy of our time. Don't get lost.
