Scientific evidence for human genetic degeneration

Scientific evidence for human genetic degeneration (Mutational load)

https://www.wired.com/story/whats-next-for-crispr/

Excerpt: "Other scientists at Harvard and the Broad Institute have been working on an even more daring tweak to the Crispr system: editing individual base pairs, one at a time. To do so, they had to design a brand-new enzyme—one not found in nature—that could chemically convert an A-T nucleotide pairing to a G-C one. It’s a small change with potentially huge implications. David Liu, the Harvard chemist whose lab did the work, estimates that about half of the 32,000 known pathogenic point mutations in humans could be fixed by that single swap." 

My comment: C>T-mutations are mostly caused by changing methylation patterns or by oxidative stress that triggers deamination at methylated cytosines. This same phenomenon is very observable in the wild: 

https://phys.org/news/2019-09-chicken-reveals-environmental-factors-chance.html

Excerpt: "In a plant study, for example, epigenetic modifications were found to be responsible for delaying flowering during the cold winter months, until spring, when temperatures are more favourable.
 

"At a CpG site, a methylated "C' is only one chemical reaction away from becoming a "T'—a different base entirely. So, while environmentally induced epigenetic modifications do not cause mutations per se, the chance of a permanent C-to-T mutation is much greater at CpG sites."

"Such 'single nucleotide polymorphisms," or SNPs for short, can change the function of a gene or even lead to genetic diseases. The so-called "breast cancer gene" BRCA1, for example, is linked to mutation at a CpG site." 

My comment: Within Icelanders, for example, there are over 20 million SNPs in their genome that has led to loss of 1,171 'genes'. 

Evolution never happened. It's all epigenetics OR loss of information.