Dual-layer epigenetic gene regulation - Biological metadata points to Intelligent Design

Information layers around information layers work like a data container


Excerpt: "How can defective gene activity leading to cancer be avoided? Researchers at the University of Zurich have now identified a mechanism by which cells pass on the regulation of genetic information through epigenetic modifications. These insights open the door to new approaches for future cancer treatments.

...Methylation marks on DNA act as molecular switches that regulate gene activity in order to coordinate the cell's specialization within the organism. How this DNA methylation is faithfully regulated, and how it can become defective, has not yet been fully resolved. However, the consequences are well known: In many cancer types, the methylation is deposited in the wrong place. This leads to genes being read incorrectly.

Dual-layer epigenetic gene regulation

Scientists at the University of Zurich have now found new processes that regulate DNA methylation. Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA. "DNMT3A places itself preferably in close vicinity to genes that play an important role for development and makes sure that the DNA methylation around these genes is maintained," explains Massimiliano Manzo, lead author of the study. "The DNA methylation around these genes works like a container that ensures that H3K27me3, another epigenetic modification, which normally regulates these genes, is positioned correctly." This means that these essential genes are regulated by two epigenetic layers.
Increasing understanding of how cancer develops

The study's findings provide important basic insights for cancer research. DNMT3A is among the most frequently mutated genes in an aggressive type of leukemia, and it plays a significant role in how this disease develops. "Our findings point toward a previously unknown function of the DNMT3A protein in the interaction of these two epigenetic modifications that are normally not directly linked. We hope that these new insights will allow us to increase our understanding of the molecular mechanisms that result in cancer and to more effectively treat this aggressive type of leukemia," explains Professor Baubec."

My comment: Using containers in maintaining the integrity of biological information requires perfect software design. The DNA seems to be controlled by incredible mechanisms that refute Darwinian claims about random mutations and selection. Cellular data containers are comparable with human designed software and programming solutions. Cellular metadata points to Intelligent Design and Creation. Don't get lost.