lncRNAs might function as barcodes for identifying genomic addresses for maintaining cellular states
lncRNAs might function as barcodes for identifying genomic addresses for maintaining cellular states
http://www.lncrnablog.com/lncrnas-might-function-as-barcodes-for-identifying-genomic-addresses-for-maintaining-cellular-states/?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork
Excerpt:"Long noncoding RNAs (lncRNAs) have been implicated in diverse biological processes, including embryonic stem cell (ESC) maintenance. However, their functional mechanisms remain largely undefined. Here, researchers from TU Dresden show that the lncRNA Panct1 regulates the transient recruitment of a putative X-chromosome-encoded protein transient octamer binding factor 1 (TOBF1), to genomic sites resembling the canonical Oct-Sox motif. TOBF1 physically interacts with Panct1 and exhibits a cell-cycle-specific punctate localization in ESCs. At the chromatin level, this correlates with its recruitment to promoters of pluripotency genes. Strikingly, mutating an octamer-like motif in Panct1 RNA abrogates the strength of TOBF1 localization and recruitment to its targets. Taken together, these data reveal a tightly controlled spatial and temporal pattern of lncRNA-mediated gene regulation in a cell-cycle-dependent manner and suggest that lncRNAs might function as barcodes for identifying genomic addresses for maintaining cellular states."
My comment: Barcoding and addressing system together point to Intelligent design and Creation. The role of lncRNAs is very important especially during embryonic development, when lncRNAs transmit the necessary information for the cellular differentiation procedure. There are over a hundred of different types of epigenetic markers that these long non coding RNA molecules carry for establishing the histone coding system, a biological database which determines almost all traits of an organism.
For the theory of evolution these lncRNAs are very truth revealing molecules. For example, the similarity of human/pig lncRNA transcripts is 57% as the corresponding number between humans and chimps is only 29.8%.
https://lncrnaworld.wordpress.com/2017/03/08/first-blog-post/
"Finally, a large number of pig lncRNAs appeared to have human homologs (57% of total identified lncRNAs) illustrating the similarities between humans and pigs at the genome level."
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0880-9
"The learned transcript similarity threshold for each pair of comparing species varied as a function of distance between species: the empirical threshold for calling a significant human-chimp alignment was 29.8 % sequence similarity."
