Human knockout genes don't support the theory of Evolution

Gene loss is more common in a culture in which marrying a relative is common


Excerpt: "Although humans have about 20,000 genes, exactly what most of them do inside our body’s cells is still murky. One way to learn more is to find people who lack a working copy of a particular gene and see how that affects their health. Such so-called knockouts are scarce in the general population. But a new study points to a more efficient way to find them: Search the DNA of people from a culture in which marrying a relative is common.

And complete knockouts—people whose two copies of a specific gene are both disabled—should be even more abundant in groups in which parents are often related because this increases a person’s chances of inheriting the same chunk of DNA from both parents. For that reason, Van Heel, Richard Durbin of the Wellcome Trust Sanger Institute in Cambridge, U.K., and co-workers sequenced the protein-coding DNA of 3222 relatively healthy British adults of Pakistani heritage, many of whose parents were first cousins.

Today in Science, the U.K. team reports that this British-Pakistani group did indeed have a lot of missing genes. Among them were 781 rare, missing genes (where these variants are found in less than 1% of the population) in about 821 individuals, about half of which had not been described before.

And one healthy mother completely lacked a gene called PRDM9 that is involved in shuffling chromosomes during the formation of eggs and sperm. Mice lacking the gene are sterile, although dogs don’t carry the gene and do fine. That humans apparently have other genes that compensate for the loss of PRDM9 is “puzzling”...

“The goal is to say, for any given gene in the genome, is it sensitive to disruption?” MacArthur says. For now, he says, “we’re still only scratching the surface” of the universe of human knockouts. "

See also:


"Loss-of-function mutations cause many mendelian diseases. Here we aimed to create a catalog of autosomal genes that are completely knocked out in humans by rare loss-of-function mutations. We sequenced the whole genomes of 2,636 Icelanders and imputed the sequence variants identified in this set into 101,584 additional chip-genotyped and phased Icelanders. We found a total of 6,795 autosomal loss-of-function SNPs and indels in 4,924 genes."

My comment: The human DNA is rapidly deteriorating. It's false science to claim that there are several genes in our dna we don't need. Of course we do. But the cell is so well designed that it is able to find alternative biological pathways even after heavy loss of biological information.

We can't observe increase in biological information in nature. However, we can observe meiotic recombinations after loss of genes and chromosomes. Information is only lost. This fact makes the theory of evolution a laughable fairytale. Don't get misled.

P.S. In Leviticus chapter 18 (KJV), God tells us that we are not to have sexual relations with the following. I think everyone now understands the reason why.

any close relative (which you will clearly see does not include cousins)
your mother
your father's wife
your sister, (whole or half) "whether she was born in the same home or elsewhere" (v.9)
your grandchild
the daughter of your father's wife (step-sister)
your father's sister (aunt) "as she is your father's close relative"
your mother's sister (aunt) "as she is your mother's close relative"
your father's brother's wife (aunt)
your son's wife
your brother's wife
with both a woman and her daughter
your wife's sister as a rival wife (to spite your first wife)
during "uncleanness of her monthly period"
with your neighbor's wife
with a member of the same sex; the Bible says "that is detestable"
with an animal; the Bible refers to this as "a perversion"